What is Factor V Leiden mutation?

Factor V Leiden-guest post and reposted with permission of the author, Cassandra Schnupps


BASIC FACTS about Factor V

  • Factor V Leiden is an inherited blood clotting disorder. It is a specific gene mutation that can result in thrombophilia (an abnormality of blood coagulation that increases the risks of blood clots forming in blood vessels).
  • People who are heterozygous (carry one gene mutation) or homozygous (carry two gene mutations) are at higher risk of developing a DVT (deep vein thrombosis).
  • Factor V Leiden is the most common clotting disorder. 3-8% of Caucasians in North America carry the gene mutation.
  • Factor V Leiden can cause miscarriages. Pregnant women with Factor V are considered high risk and need to be on a course of low molecular heparin or it’s derivative, Enoxaparin Sodium (generic name is Lovenox), during pregnancy.


  • Factor V Leiden along with other blood clotting disorders has been DIRECTLY linked to Osteonecrosis/Avascular Necrosis.  There are several clinical papers I have included on this blog concerning this fact.
  • If you have Factor V you should NEVER take steroids. Even a 20 day use of high dose Prednisone can cause ON/AVN.
  • If you have Factor V NEVER take drugs with estrogen, ie, the Pill.

Much of this information has been obtained from Dr. Charles Gleck who has worked consistently in the area of metabolic disorders. Dr. Glueck is an endocrinologist in Cincinatti, OH and is recognized internationally as an expert in treating and preventing osteonecrosis.[

Ms. Schnupps has a blog at . Her blog is solely devoted to osteonecrosis/avascular necrosis. But, why do I place a post about Factor V in this the musculoskeletal category? Factor V increases the body’s likelihood of developing a clot and clot formation greatly increases the chance that a blood clot will form, obstruct circulation to the bone and depriving it of life-sustaining oxygen and nutrients. When deprived of oxygen or nutrients for a long-enough period of time, the bone dies: osteonecrosis (bone death) or avascular (without blood) necrosis.

Also of note, for obstetric patients who have lupus or another autoimmune disease, they may be considered ‘high risk’ because if there is likelihood of increasing clotting ability, the placenta may be blocked with a clot and oxygen and life-sustaining nutrients don’t get to the baby. Thus there is a high degree of miscarriages among patients with Factor V.






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